- Shop
- Dogs
-
-
Dog Menu
-
-
- Cats
-
-
Cat Menu
-
-
- Small Furries
-
-
Small Furries Menu
-
-
- Equine
-
-
Equine Menu
-
-
- About Us
- Contact Us


Price range: £50.00 through £55.00 Inc VAT
Prescription Required
NI - Only Postage
Frontline Combo Spot-On Solution for Dogs
PRESCRIPTION NEEDED (Pom-V)
Frontline Combo Spot-On Solution for Dogs is a monthly prescription spot-on treatment against fleas, ticks and lice. Valid vet prescription required.
Frontline Combo Spot-On Solution for Dogs
Frontline Combo Spot-On Solution for Dogs
PRESCRIPTION NEEDED (Pom-V)
What Frontline Combo Spot-On Is
Frontline Combo Spot-On Solution for Dogs is a prescription-only veterinary medicine that provides effective topical protection against fleas, ticks and biting lice. It combines the active ingredients fipronil and (S)-methoprene to kill adult fleas, inhibit egg/larval development and eliminate ticks for the durations specified in the product licence.
When Vets Prescribe Frontline Combo
Veterinarians recommend Frontline Combo for dogs that:
-
Are infested with fleas or at risk of flea infestation.
-
Have or may have ticks, especially in endemic areas.
-
Require treatment for biting lice.
-
Are living in households where fleas infest pet bedding, carpets or environments shared with dogs.
The spot-on aids both treatment and prevention strategies in one monthly application.
How It Works
-
Fipronil acts by disrupting the GABA-gated chloride channels in ectoparasites, causing nerve hyper-excitation and death of fleas and ticks.
-
(S)-Methoprene is an insect growth regulator that interferes with the development of flea eggs, larvae and pupae, thus helping break the flea life-cycle.
Together, they provide sustained protection: fleas up to 8 weeks, ticks up to 4 weeks depending on dog’s weight and conditions.
Dosage & Administration
Use as directed by your veterinarian. The product is applied once monthly as a “spot-on” pipette:
-
Part the dog’s coat at the base of the neck (in front of the shoulder blades) until skin is visible.
-
Place the pipette tip on the skin and empty its contents directly in one spot.
-
Do not bath, swim or shampoo the dog for at least 48 hours post-application.
Ensure you select the correct strength for your dog’s weight bracket to avoid under-dosing.
Precautions & Warnings
-
Suitable only for dogs of the target species (various pack strengths for different weight ranges). Not for cats, ferrets or rabbits.
-
Avoid use on puppies under 8 weeks old or weighing less than 2 kg, unless advised by a vet.
-
If the dog has fever or systemic illness, check with your veterinarian before use.
-
After application, prevent licking of the treated area by other animals or children until the site is dry.
-
Store below 30 °C, in the original pack. Avoid contact with eyes or mouth. Wash hands after use.
Storage & Handling
Store in original blister and carton below 25-30 °C, protected from moisture and direct sunlight. Keep out of reach of children and other animals. Dispose of used pipettes responsibly according to local regulations (avoid water courses as product may affect aquatic organisms).
Why Buy Frontline Combo from Pet Med Direct
At Pet Med Direct we supply only genuine UK-licensed veterinary medicines. Each order for Frontline Combo is verified with your vet’s prescription before dispatch. We provide tracked, discreet UK delivery and professional support to ensure safe and effective parasite control for your dog.
Frequently Asked Questions (FAQ)
How quickly does it start working?
Fleas begin to die within 24 hours of application; tick kill may take longer depending on attachment.
Can it be used in puppies?
Yes for puppies from 8 weeks and 2 kg body weight, depending on product strength—always confirm with your vet.
What if my dog swims or is bathed soon after treatment?
Bathing or immersion within 48 hours may reduce efficacy—avoid these for at least 2 days post-application.
Is it safe for pregnant or lactating dogs?
Yes, the product is licensed for use in pregnant and lactating dogs.
Do I need a prescription?
Yes. This product is a POM-V (Prescription Only Medicine – Veterinary) and requires a valid veterinary prescription for supply.
Summary
Frontline Combo Spot-On Solution for Dogs is an advanced, prescription-only spot-on providing broad-spectrum protection against fleas, ticks and biting lice. It combines fipronil and (S)-methoprene to treat existing infestations and help prevent future ones. Administer once monthly, follow veterinary prescription and avoid bathing or swimming within 48 hours. With proper use, it helps keep your dog free from ectoparasites and improves comfort and protection.
| Size | Small, Medium, Large |
|---|















