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Palladia tablets for dogs
PRESCRIPTION NEEDED (Pom-V)
Palladia tablets for dogs are a prescription-only veterinary medicine (POM-V) containing toceranib phosphate. Palladia is used in dogs for the treatment of certain mast cell tumours (a type of skin cancer), typically non-resectable or recurrent tumours that cannot be fully removed surgically.
Palladia is a targeted tyrosine kinase inhibitor that works on specific cell-signalling pathways involved in tumour growth, blood supply and spread. It is supplied as film-coated tablets in three strengths – 10 mg, 15 mg and 50 mg – so your vet can tailor the dose to your dog’s weight and treatment protocol. Palladia must only be used under the close supervision of a veterinary surgeon, with regular check-ups and blood tests.
Key points:
Prescription-only (POM-V) anti-cancer tablets for dogs
Active ingredient: toceranib phosphate
Used to treat certain mast cell tumours that cannot be fully removed surgically
Three strengths: 10 mg, 15 mg and 50 mg film-coated tablets
Cytotoxic medicine – must be handled with care and only used exactly as directed by your vet
Palladia tablets for dogs 10 mg, 15 mg and 50 mg – targeted therapy for mast cell tumours
Palladia tablets for dogs contain toceranib phosphate, a targeted anti-cancer medicine used in dogs to treat certain mast cell tumours. Mast cell tumours are a common form of skin cancer in dogs. Some can be surgically removed, but others are difficult or impossible to remove completely or may return after surgery. In these cases, your vet may recommend Palladia as part of a wider treatment plan.
Palladia belongs to a group of medicines called tyrosine kinase inhibitors. Instead of acting like traditional chemotherapy that affects many rapidly dividing cells, Palladia targets specific receptors and pathways involved in tumour cell growth and the formation of new blood vessels that tumours use to grow and spread. This targeted action can help to slow disease progression and, in some dogs, reduce tumour size or improve clinical signs.
What Palladia tablets for dogs are used for
Your vet may prescribe Palladia tablets for dogs when:
Your dog has a confirmed mast cell tumour that cannot be completely removed with surgery
The tumour has come back after surgery or has spread locally
Your vet believes a targeted medicine may help stabilise or shrink the tumour and improve quality of life
Palladia is generally not a first-line treatment for every mast cell tumour. Your vet will normally recommend surgery and/or other therapies where appropriate and will only suggest Palladia if they feel it is the right option for your dog’s specific case.
Strengths and presentation
Palladia tablets for dogs are film-coated to reduce dust and make handling safer. They are available in three strengths:
Palladia 10 mg tablets for dogs
Palladia 15 mg tablets for dogs
Palladia 50 mg tablets for dogs
Your vet will calculate the dose based on your dog’s bodyweight and will choose a combination of tablet strengths that allows accurate dosing. You should never change the strength or number of tablets without veterinary advice.
How Palladia works
Toceranib phosphate works by inhibiting several receptor tyrosine kinases. These receptors are involved in:
Growth and division of certain tumour cells, including some mast cell tumours
Formation of new blood vessels (angiogenesis) that tumours need to grow
Other signalling pathways that can influence tumour behaviour
By blocking these signals, Palladia can help:
Slow tumour growth
Reduce the blood supply to the tumour
In some cases, shrink or stabilise the tumour
The overall aim is to help control the disease and maintain or improve your dog’s quality of life for as long as possible.
How Palladia tablets for dogs are given
Palladia tablets for dogs are given by mouth on the schedule prescribed by your vet. Dosing is usually based on bodyweight, and your vet will provide clear instructions on:
How many tablets of each strength to give
How often to give them (for example on specific days of the week)
Whether they should be given with food or on an empty stomach
General guidance (always follow your own vet’s instructions and the package leaflet):
Give Palladia exactly as prescribed; do not alter the dose or schedule yourself
If your dog vomits soon after dosing or you are unsure whether the full dose was taken, contact your vet before giving more
Do not crush or split tablets unless your vet has specifically instructed you to and shown you how to do so safely
Keep a written record or calendar of dosing days and any symptoms you notice at home
Monitoring and follow-up
Because Palladia is a potent anti-cancer medicine, ongoing monitoring is essential. Your vet will arrange regular check-ups, which may include:
Physical examinations to assess tumour size, lymph nodes and general condition
Blood tests to monitor red and white blood cells, platelets, kidney and liver function
Blood pressure checks or other tests if needed
Reviews of any side effects or changes in your dog’s behaviour, appetite or stools
In some dogs, the dose may be adjusted, paused or stopped depending on how well the tumour is responding and whether any side effects occur.
Possible side effects
As with all potent medicines, Palladia tablets for dogs can cause side effects. Your vet will discuss these with you before starting treatment. Not every dog will experience problems, but you should watch closely for any changes and contact your vet promptly if you are concerned. Commonly reported issues can include:
Digestive signs such as vomiting, diarrhoea, loss of appetite or weight loss
Lethargy or weakness
Changes in drinking and urination
Effects on blood cells, which may show as pale gums, bruising or increased susceptibility to infections
More serious reactions are less common but can occur. You should seek urgent veterinary attention if your dog:
Collapses or becomes very weak
Has persistent vomiting or diarrhoea, especially with blood
Stops eating completely
Shows black, tarry stools or signs of abdominal pain
Appears jaundiced (yellow gums or eyes)
Your vet may adjust the dose, pause treatment or switch to a different approach if necessary.
Safety, precautions and handling
Palladia tablets for dogs are cytotoxic, meaning they can harm dividing cells and pose risks to people if handled incorrectly. For this reason:
Keep Palladia tablets in their original packaging and store them safely out of sight and reach of children and other animals
Do not break or crush tablets unless absolutely necessary and only if your vet has specifically instructed you to
Wash your hands thoroughly after handling tablets or anything that may be contaminated with your dog’s saliva, urine or faeces after dosing
Pregnant women, women trying to conceive and people with compromised immune systems should avoid handling Palladia tablets or waste from treated dogs where possible
Your vet may advise extra care when cleaning up urine, faeces or vomit from your dog for a certain period after dosing. Use gloves, disposable materials and wash your hands well afterwards.
Use with other medicines
Palladia may sometimes be used alongside other treatments such as anti-nausea medicines, antibiotics, pain relief or supportive therapies. However, combining medicines must be done carefully. Always tell your vet about every prescription medicine, supplement or over-the-counter product your dog is taking.
Do not start, stop or change any other medicine while your dog is on Palladia without checking with your vet first.
What to expect from Palladia treatment
Response to Palladia varies between dogs. Some may show shrinkage or stabilisation of their mast cell tumours and an improvement in quality of life, while others may not respond as well. Your vet will discuss realistic goals and will monitor your dog over time to see how effective the treatment is.
In many cases, the focus is on:
Reducing discomfort from the tumour
Slowing disease progression
Maintaining a good quality of life for as long as possible
If Palladia stops working or side effects become difficult to manage, your vet will talk you through alternative options and supportive care.
Frequently asked questions about Palladia tablets for dogs
Is Palladia a prescription-only medicine? Yes. Palladia is a POM-V medicine. Your dog must be examined by a vet, and you must have a valid prescription before it can be supplied.
Will my dog lose their hair on Palladia? Hair loss in dogs is less common and usually less dramatic than in people receiving chemotherapy, but some coat changes or thinning can occur. Your vet can advise what is normal to expect in your dog’s case.
How long will my dog need Palladia? The duration of treatment is individual. Some dogs stay on Palladia for many months, while others may only receive it for a shorter time. Your vet will review your dog regularly and will advise you if and when treatment needs to be changed.
Can I stop Palladia if my dog seems better? No. Never stop or restart Palladia without veterinary advice. The decision to adjust or stop treatment should always be made by your vet, based on tumour response and blood test results as well as how your dog is feeling.
What should I do if I miss a dose? If you realise you have missed a dose, contact your vet or follow the advice on your prescription. Do not double up at the next dosing time unless your vet has specifically instructed this.
Always follow the instructions on your dog’s prescription, the product label and the package leaflet. If you have any questions or concerns about Palladia tablets for dogs, dosing or potential side effects, contact your vet for personalised guidance.
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